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Target
Carboxypeptidase B
Ligand
BDBM50270386
Substrate
n/a
Meas. Tech.
ChEMBL_530367 (CHEMBL968463)
Ki
7200±n/a nM
Citation
 Fernández, D; Illa, O; Avilés, FX; Branchadell, V; Vendrell, J; Ortuño, RM Thioxophosphoranyl aryl- and heteroaryloxiranes as the representants of a new class of metallocarboxypeptidase inhibitors. Bioorg Med Chem 16:4823-8 (2008) [PubMed]  Article 
Target
Name:
Carboxypeptidase B
Synonyms:
CBPB1_HUMAN | CPB | CPB1 | Carboxypeptidase B | PASP | PCPB | Pancreas-specific protein | Thrombin-activatable fibrinolysis (TAFI)
Type:
Enzyme
Mol. Mass.:
47367.43
Organism:
Homo sapiens (Human)
Description:
P15086
Residue:
417
Sequence:
MLALLVLVTVALASAHHGGEHFEGEKVFRVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEKYNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGREIQVTELLDKLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIKAYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIRYSFTFELRDTGRYGFLLPESQIRATCEETFLAIKYVASYVLEHLY
  
Inhibitor
Name:
BDBM50270386
Synonyms:
CHEMBL477076 | trans-(2RS,3RS)-3-(2-Thienyl)-2-trimethylsilyl-2-oxiran-2-yl-N,N,N',N'-tetraisopropylthiophosphonodiamide
Type:
Small organic molecule
Emp. Form.:
C21H41N2OPS2Si
Mol. Mass.:
460.752
SMILES:
CC(C)N(C(C)C)P(=S)(N(C(C)C)C(C)C)[C@@]1(O[C@H]1c1cccs1)[Si](C)(C)C |r|
Structure:
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