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TargetRegulatory protein E2
LigandBDBM50127140
Substrate/Competitorn/a
Meas. Tech.ChEMBL_532974
Kd 210000±n/a nM
Citation Saitoh, TKuramochi, KImai, TTakata, KTakehara, MKobayashi, SSakaguchi, KSugawara, F Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro. Bioorg Med Chem16:5815-25 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Regulatory protein E2
Name:Regulatory protein E2
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:45494.82
Organism:Human papillomavirus type 1a
Description:ChEMBL_532977
Residue:401
Sequence:
MENLSSRLDLLQEQLMNLYEQDSKLIEDQIKQWNLIRQEQVLFHFARKNGVMRIGLQAVP
SLASSQEKAKTAIEMVLHLESLKDSPYGTEDWSLQDTSRELFLAPPAGTFKKSGSTLEVT
YDNNPDNQTRHTIWNHVYYQNGDDVWRKVSSGVDAVGVYYLEHDGYKNYYVLFAEEASKY
STTGQYAVNYRGKRFTNVMSSTSSPRAAGAPAVHSDYPTLSESDTAQQSTSIDYTELPGQ
GETSQVRQRQQKTPVRRRPYGRRRSRSPRGGGRREGESTPSRTPGSVPSARDVGSIHTTP
QKGHSSRLRRLLQEAWDPPVVCVKGGANQLKCLRYRLKASTQVDFDSISTTWHWTDRKNT
ERIGSARMLVKFIDEAQREKFLERVALPRSVSVFLGQFNGS
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  Blast E-value cutoff:
BDBM50127140
NameBDBM50127140
Synonyms:(-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside | 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside) | 4-demethylepipodophyllotoxin beta-D-ethylideneglucoside | 9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one | CHEMBL44657 | Etoposide (ET) | TRANS-ETOPOSIDE | VP-16 | etoposide
TypeSmall organic molecule
Emp. Form.C29H32O13
Mol. Mass.588.5566
SMILESCOc1cc(cc(OC)c1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@@H](C)O[C@H]3[C@H](O)[C@H]2O)c2cc3OCOc3cc12 |r|
Structure
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n/a