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Target
Melanocortin receptor 3
Ligand
BDBM50261197
Substrate
n/a
Meas. Tech.
ChEMBL_555530 (CHEMBL963790)
Ki
200±n/a nM
Citation
 Chen, C; Tucci, FC; Jiang, W; Tran, JA; Fleck, BA; Hoare, SR; Wen, J; Chen, T; Johns, M; Markison, S; Foster, AC; Marinkovic, D; Chen, CW; Arellano, M; Harman, J; Saunders, J; Bozigian, H; Marks, D Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists. Bioorg Med Chem 16:5606-18 (2008) [PubMed]  Article 
Target
Name:
Melanocortin receptor 3
Synonyms:
MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4)
Type:
Enzyme
Mol. Mass.:
36044.86
Organism:
Homo sapiens (Human)
Description:
P41968
Residue:
323
Sequence:
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG
  
Inhibitor
Name:
BDBM50261197
Synonyms:
1-{2-[(1S)-(Methylaminoacetamido)-2-methylpropyl]-4-chlorophenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine | CHEMBL525177
Type:
Small organic molecule
Emp. Form.:
C27H36Cl2N4O2
Mol. Mass.:
519.506
SMILES:
CNCC(=O)N[C@@H](C(C)C)c1cc(Cl)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: