Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 2
Ligand
BDBM24631
Substrate
n/a
Meas. Tech.
ChEMBL_553548 (CHEMBL958731)
IC50
9100±n/a nM
Citation
 Congreve, M; Chessari, G; Tisi, D; Woodhead, AJ Recent developments in fragment-based drug discovery. J Med Chem 51:3661-80 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM24631
Synonyms:
4-[(6-chloropyrazin-2-yl)amino]benzene-1-sulfonamide | 4-[(6-chloropyrazin-2-yl)amino]benzenesulfonamide, 10 | CHEMBL487738
Type:
Small organic molecule
Emp. Form.:
C10H9ClN4O2S
Mol. Mass.:
284.722
SMILES:
NS(=O)(=O)c1ccc(Nc2cncc(Cl)n2)cc1
Structure:
Search PDB for entries with ligand similarity: