Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50261131
Substrate
n/a
Meas. Tech.
ChEMBL_552367 (CHEMBL1005957)
Ki
2±n/a nM
Citation
 Smith, TA; Yang, X; Wu, H; Pouw, B; Matsumoto, RR; Coop, A Trifluoromethoxyl substituted phenylethylene diamines as high affinity sigma receptor ligands with potent anti-cocaine actions. J Med Chem 51:3322-5 (2008) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50261131
Synonyms:
CHEMBL498775 | N-Methyl-2-pyrrolidin-1-yl-N-{2-[3-(trifluoromethoxy)phenyl]-ethyl}ethanamine
Type:
Small organic molecule
Emp. Form.:
C16H23F3N2O
Mol. Mass.:
316.3618
SMILES:
CN(CCN1CCCC1)CCc1cccc(OC(F)(F)F)c1
Structure:
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