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TargetLanosterol synthase
LigandBDBM50271620
Substrate/Competitorn/a
Meas. Tech.ChEMBL_556115
IC50 32±n/a nM
Citation Fouchet, MHDonche, FMartin, CBouillot, AJunot, CBoullay, ABPotvain, FMagny, SDCoste, HWalker, MIssandou, MDodic, N Design and evaluation of a novel series of 2,3-oxidosqualene cyclase inhibitors with low systemic exposure, relationship between pharmacokinetic properties and ocular toxicity. Bioorg Med Chem16:6218-32 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lanosterol synthase
Name:Lanosterol synthase
Synonyms:2,3-epoxysqualene--lanosterol cyclase | OSC | Oxidosqualene--lanosterol cyclase
Type:PROTEIN
Mol. Mass.:83309.32
Organism:Homo sapiens (Human)
Description:ChEMBL_84
Residue:732
Sequence:
MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDT
KNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLP
AGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNIL
HKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM
SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALL
NLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQE
HVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRL
SQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPR
ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQA
LKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMG
QTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLM
AVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFS
QLYPERALAGHP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50271620
NameBDBM50271620
Synonyms:1-[4-Chlorophenylsulfonyl]-4-[4-(dimethylaminomethyl)phenylmethyl]-piperazine | CHEMBL521168
TypeSmall organic molecule
Emp. Form.C20H26ClN3O2S
Mol. Mass.407.957
SMILESCN(C)Cc1ccc(CN2CCN(CC2)S(=O)(=O)c2ccc(Cl)cc2)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a