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Target
IgG receptor FcRn large subunit p51
Ligand
BDBM50270783
Substrate
n/a
Meas. Tech.
ChEMBL_552585 (CHEMBL956457)
pH
6±n/a
Kd
5700±n/a nM
Comments
extracted
Citation
 Mezo, AR; McDonnell, KA; Castro, A; Fraley, C Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction. Bioorg Med Chem 16:6394-405 (2008) [PubMed]  Article 
Target
Name:
IgG receptor FcRn large subunit p51
Synonyms:
FCGRN_HUMAN | FCGRT | FCRN
Type:
PROTEIN
Mol. Mass.:
39742.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_627631
Residue:
365
Sequence:
MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
  
Inhibitor
Name:
BDBM50270783
Synonyms:
CHEMBL508411 | QRFCTGHFGGLYPCNGP
Type:
Small organic molecule
Emp. Form.:
C82H114N24O22S2
Mol. Mass.:
1852.06
SMILES:
CC(C)C[C@@H]1NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O |r,wU:120.127,98.112,41.133,127.135,27.28,4.3,61.64,54.60,76.80,91.97,wD:109.123,45.100,16.16,50.77,(33.75,-3.64,;33.75,-5.18,;35.1,-5.94,;32.42,-5.94,;32.42,-7.49,;31.09,-8.26,;29.75,-7.49,;29.75,-5.94,;28.42,-8.26,;27.09,-7.49,;25.75,-8.26,;25.75,-9.8,;24.41,-7.49,;23.09,-8.26,;21.75,-7.49,;21.75,-5.94,;20.42,-8.26,;20.42,-9.8,;21.75,-10.57,;23.08,-9.8,;24.42,-10.57,;24.42,-12.1,;23.08,-12.89,;21.75,-12.12,;19.09,-7.49,;17.76,-8.26,;17.76,-9.8,;16.42,-7.49,;16.42,-5.94,;17.76,-5.18,;19.17,-5.81,;20.19,-4.66,;19.42,-3.33,;17.92,-3.66,;15.08,-8.26,;13.75,-7.49,;13.75,-5.94,;12.42,-8.26,;11.09,-7.49,;9.75,-8.26,;9.75,-9.8,;8.41,-7.49,;7.08,-8.26,;5.74,-7.49,;5.74,-5.94,;4.42,-8.26,;4.42,-9.8,;5.74,-10.57,;32.66,-15.14,;34,-14.38,;35.33,-15.15,;36.65,-14.38,;36.67,-12.84,;35.34,-12.07,;38,-12.07,;39.41,-12.75,;40.35,-11.38,;39.32,-10.04,;37.76,-10.57,;36.41,-9.8,;35.1,-10.57,;36.41,-8.26,;37.76,-7.49,;37.76,-5.94,;36.44,-5.18,;36.43,-3.65,;37.75,-2.87,;37.75,-1.33,;39.09,-3.63,;39.11,-5.17,;35.1,-7.49,;33.75,-8.26,;33.75,-9.8,;35.31,-16.69,;36.64,-17.46,;33.98,-17.45,;33.97,-18.99,;35.3,-19.77,;35.3,-21.31,;33.97,-22.07,;36.64,-22.09,;32.63,-19.76,;31.31,-18.99,;32.63,-21.3,;31.29,-22.06,;31.29,-23.6,;32.62,-24.38,;29.96,-24.37,;29.65,-26.03,;27.98,-26.24,;27.26,-24.73,;28.55,-23.86,;28.35,-22.34,;26.92,-21.76,;29.56,-21.39,;3.08,-7.49,;1.75,-8.26,;1.75,-9.8,;.42,-7.49,;.42,-5.94,;1.75,-5.18,;3.09,-5.95,;4.42,-5.18,;4.42,-3.64,;3.08,-2.87,;1.75,-3.64,;-.91,-8.26,;-2.25,-7.49,;-2.25,-5.94,;-3.58,-8.26,;-3.58,-9.8,;-2.25,-10.57,;-2.25,-12.1,;-.91,-12.88,;-.91,-14.42,;-2.25,-15.19,;.42,-15.19,;-4.92,-7.49,;-6.26,-8.26,;-6.26,-9.8,;-7.59,-7.49,;-8.92,-8.26,;-7.59,-5.94,;-6.26,-5.18,;-6.26,-3.64,;-7.59,-2.87,;-4.92,-2.87,;8.41,-5.94,;7.08,-5.18,;9.75,-5.18,)|
Structure:
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