Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit rho-1
Ligand
BDBM50032973
Substrate
n/a
Meas. Tech.
ChEMBL_554600 (CHEMBL964514)
IC50
5500±n/a nM
Citation
 Kumar, RJ; Chebib, M; Hibbs, DE; Kim, HL; Johnston, GA; Salam, NK; Hanrahan, JR Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships. J Med Chem 51:3825-40 (2008) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit rho-1
Synonyms:
GABA receptor rho-1 subunit | GABA-C receptor | GABRR1 | GBRR1_HUMAN
Type:
PROTEIN
Mol. Mass.:
55892.34
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456653
Residue:
479
Sequence:
MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
  
Inhibitor
Name:
BDBM50032973
Synonyms:
((Z)-3-Amino-propenyl)-methyl-phosphinic acid | 3-aminoprop-1-enyl(methyl)phosphinic acid | CGP44530 | CGP70523 | CHEMBL109375 | CHEMBL430510
Type:
Small organic molecule
Emp. Form.:
C4H10NO2P
Mol. Mass.:
135.1015
SMILES:
CP(O)(=O)CCC=N
Structure:
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