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TargetDipeptidyl peptidase 2 (DPP II)
LigandBDBM50243316
Substrate/Competitorn/a
Meas. Tech.ChEMBL_492000
IC50 41000±n/a nM
Citation Van Goethem, SVan der Veken, PDubois, VSoroka, ALambeir, AMChen, XHaemers, AScharpé, SDe Meester, IAugustyns, K Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: isoindoline containing inhibitors. Bioorg Med Chem Lett18:4159-62 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dipeptidyl peptidase 2 (DPP II)
Name:Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4)
Synonyms:DAP II | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 (DPP2) | Dipeptidyl peptidase II (DDP-II) | Dipeptidyl peptidase II (DPP II) | carboxytripeptidase | dipeptidyl arylamidase II | dipeptidyl(amino)peptidase II | dipeptidylarylamidase
Type:Protein
Mol. Mass.:54339.29
Organism:Homo sapiens (Human)
Description:Q9UHL4
Residue:492
Sequence:
MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS
TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA
QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW
AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ
QPALRGGPRLSL
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  Blast E-value cutoff:
BDBM50243316
NameBDBM50243316
Synonyms:((2S,4R)-4-aminopyrrolidin-2-yl)(isoindolin-2-yl)methanone | CHEMBL452520
TypeSmall organic molecule
Emp. Form.C13H17N3O
Mol. Mass.231.2936
SMILESN[C@H]1CN[C@@H](C1)C(=O)N1Cc2ccccc2C1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a