Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM50242928
Substrate
n/a
Meas. Tech.
ChEMBL_487488 (CHEMBL1016550)
IC50
45±n/a nM
Citation
 Shi, ZCDevasagayaraj, AGu, KJin, HMarinelli, BSamala, LScott, SStouch, TTunoori, AWang, YZang, YZhang, CKimball, SDMain, AJSun, WYang, QNouraldeen, AYu, XQBuxton, EPatel, SNguyen, NSwaffield, JPowell, DRWilson, ALiu, Q Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders. J Med Chem 51:3684-7 (2008) [PubMed]  Article 
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
50990.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361824
Residue:
444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
  
Inhibitor
Name:
BDBM50242928
Synonyms:
(S)-2-amino-3-{4-[5-(3-cyclopentyloxy-4-methoxy-benzyl amino)-pyrazin-2-yl]-phenyl}-propionic acid | CHEMBL469462
Type:
Small organic molecule
Emp. Form.:
C26H30N4O4
Mol. Mass.:
462.5408
SMILES:
COc1ccc(CNc2cnc(cn2)-c2ccc(C[C@H](N)C(O)=O)cc2)c(OC2CCCC2)c1 |r|
Structure:
Search PDB for entries with ligand similarity: