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Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM50243619
Substrate
n/a
Meas. Tech.
ChEMBL_487489 (CHEMBL1016551)
EC50
70±n/a nM
Citation
Shi, ZC; Devasagayaraj, A; Gu, K; Jin, H; Marinelli, B; Samala, L; Scott, S; Stouch, T; Tunoori, A; Wang, Y; Zang, Y; Zhang, C; Kimball, SD; Main, AJ; Sun, W; Yang, Q; Nouraldeen, A; Yu, XQ; Buxton, E; Patel, S; Nguyen, N; Swaffield, J; Powell, DR; Wilson, A; Liu, Q Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders. J Med Chem 51:3684-7 (2008) [PubMed] Article
More Info.:
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH1_RAT | Tph | Tph1 | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
51069.51
Organism:
Rattus norvegicus
Description:
ChEMBL_1361815
Residue:
444
Sequence:
MIEDNKENKDHSSERGRVTLIFSLKNEVGGLIKALKIFQENHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFPLLKSHTTVLSVDSPDQLPEKEDVMETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNVPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELRHALSGHAKVKPFDPKVACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRPFGVKYNPYTQSIQVLRDSKSITSAMNELRHDLDVVNDALARVSRWPSV
Inhibitor
Name:
BDBM50243619
Synonyms:
(S) -2-amino-3-[4-(2-amino-6-[2,2,2-trifluoro-1-(2-(3-trifluoromethyl-pyrazol-1-yl-phenyl)-ethoxy]-pyrimidin-4-yl]-phenyl-propionic acid | CHEMBL479924
Type:
Small organic molecule
Emp. Form.:
C25H20F6N6O3
Mol. Mass.:
566.4551
SMILES:
N[C@@H](Cc1ccc(cc1)-c1cc(OC(c2ccccc2-n2ccc(n2)C(F)(F)F)C(F)(F)F)nc(N)n1)C(O)=O |r|