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TargetC5a anaphylatoxin chemotactic receptor (C5aR)
LigandBDBM50251636
Substrate/Competitorn/a
Meas. Tech.ChEMBL_488511
IC50>10000±n/a nM
Citation Gong, YBarbay, JKBuntinx, MLi, JWauwe, JVClaes, CLommen, GVHornby, PJHe, W Design and optimization of aniline-substituted tetrahydroquinoline C5a receptor antagonists. Bioorg Med Chem Lett18:3852-5 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C5a anaphylatoxin chemotactic receptor (C5aR)
Name:C5a anaphylatoxin chemotactic receptor
Synonyms:C5a anaphylatoxin chemotactic receptor | C5a-R | C5aR | CD_antigen=CD88
Type:Enzyme
Mol. Mass.:39347.68
Organism:Homo sapiens (Human)
Description:P21730
Residue:350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIY
VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50251636
NameBDBM50251636
Synonyms:(+/-)-2-(2,6-dimethylphenyl)-4-methoxy-N-(3-methoxy-2-methylphenyl)-N-methyl-5,6,7,8-tetrahydroquinolin-5-amine | CHEMBL480319
TypeSmall organic molecule
Emp. Form.C27H32N2O2
Mol. Mass.416.5552
SMILESCOc1cccc(N(C)C2CCCc3nc(cc(OC)c23)-c2c(C)cccc2C)c1C
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a