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TargetSerotonin (5-HT) receptor
LigandBDBM50262582
Substrate/Competitorn/a
Meas. Tech.ChEMBL_491041
EC50 323±n/a nM
Citation Siracusa, MASalerno, LModica, MNPittalà, VRomeo, GAmato, MENowak, MBojarski, AJMereghetti, ICagnotto, AMennini, T Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands. J Med Chem51:4529-38 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serotonin (5-HT) receptor
Name:Serotonin 1 (5-HT1) receptor
Synonyms:5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A | 5-hydroxytryptamine receptor 1A (5HT1A) | G-21 | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46445.29
Organism:Rattus norvegicus (rat)
Description:Binding assays were performed using rat hippocampal membranes.
Residue:422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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  Blast E-value cutoff:
BDBM50262582
NameBDBM50262582
Synonyms:2-[[3-[4-(Pyridin-2-yl)-1-piperazinyl]propyl]thio]benzothiazole | CHEMBL478413
TypeSmall organic molecule
Emp. Form.C19H22N4S2
Mol. Mass.370.535
SMILESC(CSc1nc2ccccc2s1)CN1CCN(CC1)c1ccccn1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a