Reaction Details Report a problem with these data
Target
Group IIE secretory phospholipase A2
Ligand
BDBM50263052
Substrate
n/a
Meas. Tech.
ChEMBL_489274 (CHEMBL990830)
IC50
90±n/a nM
Citation
 Oslund, RC; Cermak, N; Gelb, MH Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. J Med Chem 51:4708-14 (2008) [PubMed]  Article 
Target
Name:
Group IIE secretory phospholipase A2
Synonyms:
GIIE sPLA2 | PA2GE_HUMAN | PLA2G2E | Phosphatidylcholine 2-acylhydrolase GIIE | sPLA(2)-IIE
Type:
PROTEIN
Mol. Mass.:
15997.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_489274
Residue:
142
Sequence:
MKSPHVLVFLCLLVALVTGNLVQFGVMIEKMTGKSALQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAGRTTCQRLTCECDKRAALCFRRNLGTYNRKYAHYPNKLCTGPTPPC
  
Inhibitor
Name:
BDBM50263052
Synonyms:
2-[3-Biphenyl-2-ylmethyl-2-ethyl-8-(2-oxo-propoxy)-indolizin-1-yl]-2-oxo-acetamide | CHEMBL517821
Type:
Small organic molecule
Emp. Form.:
C28H26N2O4
Mol. Mass.:
454.517
SMILES:
CCc1c(Cc2ccccc2-c2ccccc2)n2cccc(OCC(C)=O)c2c1C(=O)C(N)=O
Structure:
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