Reaction Details Report a problem with these data
Target
Group 10 secretory phospholipase A2
Ligand
BDBM50263052
Substrate
n/a
Meas. Tech.
ChEMBL_489280 (CHEMBL990836)
IC50
>1600±n/a nM
Citation
 Oslund, RC; Cermak, N; Gelb, MH Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. J Med Chem 51:4708-14 (2008) [PubMed]  Article 
Target
Name:
Group 10 secretory phospholipase A2
Synonyms:
Group X secretory phospholipase A2 | PA2GX_HUMAN | PLA2G10
Type:
PROTEIN
Mol. Mass.:
18153.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1442449
Residue:
165
Sequence:
MGPLPVCLPIMLLLLLPSLLLLLLLPGPGSGEASRILRVHRRGILELAGTVGCVGPRTPIAYMKYGCFCGLGGHGQPRDAIDWCCHGHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGPAENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCEPDSPKCD
  
Inhibitor
Name:
BDBM50263052
Synonyms:
2-[3-Biphenyl-2-ylmethyl-2-ethyl-8-(2-oxo-propoxy)-indolizin-1-yl]-2-oxo-acetamide | CHEMBL517821
Type:
Small organic molecule
Emp. Form.:
C28H26N2O4
Mol. Mass.:
454.517
SMILES:
CCc1c(Cc2ccccc2-c2ccccc2)n2cccc(OCC(C)=O)c2c1C(=O)C(N)=O
Structure:
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