Reaction Details Report a problem with these data
Target
Group IID secretory phospholipase A2
Ligand
BDBM50262843
Substrate
n/a
Meas. Tech.
ChEMBL_489272 (CHEMBL990828)
IC50
700±n/a nM
Citation
 Oslund, RC; Cermak, N; Gelb, MH Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. J Med Chem 51:4708-14 (2008) [PubMed]  Article 
Target
Name:
Group IID secretory phospholipase A2
Synonyms:
PA2GD_HUMAN | PLA2G2D | SPLASH
Type:
PROTEIN
Mol. Mass.:
16554.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_199689
Residue:
145
Sequence:
MELALLCGLVVMAGVIPIQGGILNLNKMVKQVTGKMPILSYWPYGCHCGLGGRGQPKDATDWCCQTHDCCYDHLKTQGCSIYKDYYRYNFSQGNIHCSDKGSWCEQQLCACDKEVAFCLKRNLDTYQKRLRFYWRPHCRGQTPGC
  
Inhibitor
Name:
BDBM50262843
Synonyms:
Benzenesulfonyl-2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-isobutyl-1H-indol-4-yloxy)acetamide | CHEMBL479251
Type:
Small organic molecule
Emp. Form.:
C29H29N3O6S
Mol. Mass.:
547.622
SMILES:
CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cccc2n1Cc1ccccc1
Structure:
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