Target
Mitogen-activated protein kinase 14
Ligand
BDBM50262916
Substrate
n/a
Meas. Tech.
ChEMBL_490152 (CHEMBL983811)
Ki
7±n/a nM
Citation
 Angell, RAston, NMBamborough, PBuckton, JBCockerill, SdeBoeck, SJEdwards, CDHolmes, DSJones, KLLaine, DIPatel, SSmee, PASmith, KJSomers, DOWalker, AL Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. Bioorg Med Chem Lett 18:4428-32 (2008) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50262916
Synonyms:
6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopropylamide 4'-[(4-methoxy-phenyl)-amide] | CHEMBL478819
Type:
Small organic molecule
Emp. Form.:
C25H24N2O3
Mol. Mass.:
400.4697
SMILES:
COc1ccc(NC(=O)c2ccc(cc2)-c2cc(ccc2C)C(=O)NC2CC2)cc1
Structure:
Search PDB for entries with ligand similarity: