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Target
NAD-dependent protein deacetylase sirtuin-2
Ligand
BDBM50261974
Substrate
n/a
Meas. Tech.
ChEMBL_514685 (CHEMBL976457)
IC50
57000±n/a nM
Citation
 Huhtiniemi, T; Suuronen, T; Rinne, VM; Wittekindt, C; Lahtela-Kakkonen, M; Jarho, E; Wallén, EA; Salminen, A; Poso, A; Leppänen, J Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors. J Med Chem 51:4377-80 (2008) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-2
Synonyms:
NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2)
Type:
Hydrolase
Mol. Mass.:
43172.62
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
389
Sequence:
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
  
Inhibitor
Name:
BDBM50261974
Synonyms:
3-[[3-(4-tertbutylphenyl)1,2,4-oxadiazole-5-carbonyl]amino]-1-[3-trifluoromethylphenyl]thiourea | CHEMBL512966
Type:
Small organic molecule
Emp. Form.:
C21H20F3N5O2S
Mol. Mass.:
463.476
SMILES:
CC(C)(C)c1ccc(cc1)-c1noc(n1)C(=O)NNC(=S)Nc1cccc(c1)C(F)(F)F
Structure:
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