Reaction Details
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Gamma-aminobutyric acid receptor subunit alpha-4
Ligand
BDBM50273002
Substrate
n/a
Meas. Tech.
ChEMBL_514408 (CHEMBL971726)
EC50
128000±n/a nM
Citation
Jansen, M; Rabe, H; Strehle, A; Dieler, S; Debus, F; Dannhardt, G; Akabas, MH; Lüddens, H Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site. J Med Chem 51:4430-48 (2008) [PubMed] Article More Info.:
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-4
Synonyms:
GBRA4_RAT | Gabra4 | Gamma-aminobutyric acid receptor (GABA(A)) subunit alpha-4
Type:
Enzyme
Mol. Mass.:
60972.37
Organism:
Rattus norvegicus (Rat)
Description:
P28471
Residue:
552
Sequence:
MVSVQKVPAIVLCSGVSLALLHVLCLATCLNESPGQNSKDEKLCPENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMQKAKKKISKPPPEVPAAPVLKEKHTETSLQNTHANLNMRKRTNALVHSESDVNSRTEVGNHSSKTTAAQESSETTPKAHLASSPNPFSRANAAETISAAARGLSSAASPSPHGTLQPAPLRSASARPAFGARLGRIKTTVNTTGVPGNVSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKSESLM
Inhibitor
Name:
BDBM50273002
Synonyms:
5-Aminomethyl-3H-[1,3,4]oxadiazol-2-one Hydrochloride | CHEMBL454608
Type:
Small organic molecule
Emp. Form.:
C3H5N3O2
Mol. Mass.:
115.0907
SMILES:
NCc1n[nH]c(=O)o1
Structure:
