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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50273019
Substrate
n/a
Meas. Tech.
ChEMBL_514884 (CHEMBL972692)
EC50
60±n/a nM
Citation
 Kasuga, J; Oyama, T; Hirakawa, Y; Makishima, M; Morikawa, K; Hashimoto, Y; Miyachi, H Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: effect of introduction of fluorine at the linker part. Bioorg Med Chem Lett 18:4525-8 (2008) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50273019
Synonyms:
(+/-)-2-{3-[(4-Adamantan-1-yl-2-fluoro-benzoylamino)-methyl]-4-methoxy-benzyl}-butyric acid | CHEMBL456752
Type:
Small organic molecule
Emp. Form.:
C30H36FNO4
Mol. Mass.:
493.6095
SMILES:
CCC(Cc1ccc(OC)c(CNC(=O)c2ccc(cc2F)C23CC4CC(CC(C4)C2)C3)c1)C(O)=O |TLB:18:22:25.24.29:27,THB:23:24:27:31.22.30,23:22:25.24.29:27,30:22:25:29.28.27,30:28:25:31.23.22,18:22:25:29.28.27|
Structure:
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