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Target
Cyclin-dependent kinase 1
Ligand
BDBM50245443
Substrate
n/a
Meas. Tech.
ChEMBL_512836 (CHEMBL972549)
IC50
>100000±n/a nM
Citation
 Hughes, TV; Xu, G; Wetter, SK; Connolly, PJ; Emanuel, SL; Karnachi, P; Pollack, SR; Pandey, N; Adams, M; Moreno-Mazza, S; Middleton, SA; Greenberger, LM A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: design, synthesis, and biological activity. Bioorg Med Chem Lett 18:4896-9 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
  
Inhibitor
Name:
BDBM50245443
Synonyms:
4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(4-methoxyphenyl)pyrimidine-5-carboxamide | CHEMBL472383
Type:
Small organic molecule
Emp. Form.:
C25H22ClN5O3
Mol. Mass.:
475.927
SMILES:
COc1ccc(NC(=O)c2c(N)ncnc2Nc2ccc(OCc3ccccc3)c(Cl)c2)cc1
Structure:
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