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Target
Cholinesterase
Ligand
BDBM50272490
Substrate
n/a
Meas. Tech.
ChEMBL_510557 (CHEMBL998780)
IC50
4000±n/a nM
Citation
 Devkota, KP; Lenta, BN; Wansi, JD; Choudhary, MI; Kisangau, DP; Naz, Q; Samreen, na; Sewald, N Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. J Nat Prod 71:1481-4 (2008) [PubMed]  Article 
Target
Name:
Cholinesterase
Synonyms:
Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase
Type:
Homotetramer
Mol. Mass.:
68422.27
Organism:
Homo sapiens (Human)
Description:
P06276
Residue:
602
Sequence:
MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL
  
Inhibitor
Name:
BDBM50272490
Synonyms:
(20S)-20-(N-dimethylamino)-3beta-(N-dimethylamino)-pregn-4,14-diene | CHEMBL496488
Type:
Small organic molecule
Emp. Form.:
C25H42N2
Mol. Mass.:
370.6144
SMILES:
C[C@@H]([C@H]1CC=C2[C@@H]3CCC4=C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)N(C)C)N(C)C |r,t:4,9|
Structure:
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