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Target
Protein kinase C alpha type
Ligand
BDBM50244799
Substrate
n/a
Meas. Tech.
ChEMBL_512395 (CHEMBL979906)
Ki
15.5±n/a nM
Citation
 Duan, D; Sigano, DM; Kelley, JA; Lai, CC; Lewin, NE; Kedei, N; Peach, ML; Lee, J; Abeyweera, TP; Rotenberg, SA; Kim, H; Kim, YH; El Kazzouli, S; Chung, JU; Young, HA; Young, MR; Baker, A; Colburn, NH; Haimovitz-Friedman, A; Truman, JP; Parrish, DA; Deschamps, JR; Perry, NA; Surawski, RJ; Blumberg, PM; Marquez, VE Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities. J Med Chem 51:5198-220 (2008) [PubMed]  Article 
Target
Name:
Protein kinase C alpha type
Synonyms:
KPCA_MOUSE | Pkca | Prkca | Protein kinase C | Protein kinase C alpha | Protein kinase C alpha type
Type:
Enzyme Catalytic Domain
Mol. Mass.:
76858.67
Organism:
MOUSE
Description:
Protein kinase C 0 MOUSE::P20444
Residue:
672
Sequence:
MADVYPANDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINDPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSNLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKAHNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPVGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLNNVMLNSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKQPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV
  
Inhibitor
Name:
BDBM50244799
Synonyms:
CHEMBL461562 | rac-(E/Z)-(4-(4-(trifluoromethyl)benzylidene)-2-(hydroxymethyl)-5-oxo-tetrahydrofuran-2-yl)methyl 2-ethylhexanoate
Type:
Small organic molecule
Emp. Form.:
C22H27F3O5
Mol. Mass.:
428.442
SMILES:
CCCCC(CC)C(=O)OCC1(CO)C\C(=C\c2ccc(cc2)C(F)(F)F)C(=O)O1
Structure:
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