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Target
Ras guanyl-releasing protein 3
Ligand
BDBM50244867
Substrate
n/a
Meas. Tech.
ChEMBL_512396 (CHEMBL979907)
Ki
8±n/a nM
Citation
 Duan, D; Sigano, DM; Kelley, JA; Lai, CC; Lewin, NE; Kedei, N; Peach, ML; Lee, J; Abeyweera, TP; Rotenberg, SA; Kim, H; Kim, YH; El Kazzouli, S; Chung, JU; Young, HA; Young, MR; Baker, A; Colburn, NH; Haimovitz-Friedman, A; Truman, JP; Parrish, DA; Deschamps, JR; Perry, NA; Surawski, RJ; Blumberg, PM; Marquez, VE Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities. J Med Chem 51:5198-220 (2008) [PubMed]  Article 
Target
Name:
Ras guanyl-releasing protein 3
Synonyms:
GRP3 | GRP3_HUMAN | KIAA0846 | RAS guanyl releasing protein 3 | RASGRP3
Type:
PROTEIN
Mol. Mass.:
78335.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1364407
Residue:
690
Sequence:
MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRVHAGVDVVDRGTEFELDQDEGEETRQDGEDG
  
Inhibitor
Name:
BDBM50244867
Synonyms:
CHEMBL472171 | rac-(E)-{2-(Hydroxymethyl)-4-[(3-nitrophenyl)methylene]-5-oxo-2-2,3-dihydrofuryl}methyl 4-(dimethylamino)benzoate
Type:
Small organic molecule
Emp. Form.:
C22H22N2O7
Mol. Mass.:
426.4193
SMILES:
CN(C)c1ccc(cc1)C(=O)OCC1(CO)C\C(=C/c2cccc(c2)[N+]([O-])=O)C(=O)O1
Structure:
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