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Target
Prostasin
Ligand
BDBM50247001
Substrate
n/a
Meas. Tech.
ChEMBL_557785 (CHEMBL953294)
Ki
130±n/a nM
Citation
 Tully, DC; Vidal, A; Chatterjee, AK; Williams, JA; Roberts, MJ; Petrassi, HM; Spraggon, G; Bursulaya, B; Pacoma, R; Shipway, A; Schumacher, AM; Danahay, H; Harris, JL Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design. Bioorg Med Chem Lett 18:5895-9 (2008) [PubMed]  Article 
Target
Name:
Prostasin
Synonyms:
PRSS8 | PRSS8_HUMAN
Type:
PROTEIN
Mol. Mass.:
36426.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_557785
Residue:
343
Sequence:
MAQKGVLGPGQLGAVAILLYLGLLRSGTGAEGAEAPCGVAPQARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRVVPQTQESQPDSNLCGSHLAFSSAPAQGLLRPILFLPLGLALGLLSPWLSEH
  
Inhibitor
Name:
BDBM50247001
Synonyms:
CHEMBL448873 | Phenyl-carbamic acid (3R,5S)-5-[(S)-5-amino-1-(benzooxazole-2-carbonyl)-pentylcarbamoyl]-1-((R)-2-benzyloxycarbonylamino-4-phenyl-butyryl)-pyrrolidin-3-yl ester
Type:
Small organic molecule
Emp. Form.:
C43H46N6O8
Mol. Mass.:
774.8607
SMILES:
NCCCC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)[C@@H](CCc1ccccc1)NC(=O)OCc1ccccc1)OC(=O)Nc1ccccc1)C(=O)c1nc2ccccc2o1 |r|
Structure:
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