Reaction Details Report a problem with these data
Target
B1 bradykinin receptor
Ligand
BDBM50264529
Substrate
n/a
Meas. Tech.
ChEMBL_535280 (CHEMBL982605)
IC50
3219±n/a nM
Citation
 Guo, Q; Chandrasekhar, J; Ihle, D; Wustrow, DJ; Chenard, BL; Krause, JE; Hutchison, A; Alderman, D; Cheng, C; Cortright, D; Broom, D; Kershaw, MT; Simmermacher-Mayer, J; Peng, Y; Hodgetts, KJ 1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists. Bioorg Med Chem Lett 18:5027-31 (2008) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
BDKRB1 | BKRB1_MACFA
Type:
PROTEIN
Mol. Mass.:
40231.64
Organism:
Macaca fascicularis
Description:
ChEMBL_535280
Residue:
352
Sequence:
MASWPPLQLQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICSFGLLGNLFVLLVFLLPRRRLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGIIKANLFISIFLVVAISQDRYCVLVHPMASRRRQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILAFLLPLAAIIFFNYHILASLRGREEVSRTRCGGSKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFLAFTNSSLNPVIYVFAGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50264529
Synonyms:
(1-Benzyl-1H-benzoimidazol-2-yl)-{(R)-2-[4-(1-methyl-piperidin-4-yl)-piperazine-1-carbonyl]-pyrrolidin-1-yl}-methanone | CHEMBL483036
Type:
Small organic molecule
Emp. Form.:
C30H38N6O2
Mol. Mass.:
514.6617
SMILES:
CN1CCC(CC1)N1CCN(CC1)C(=O)[C@H]1CCCN1C(=O)c1nc2ccccc2n1Cc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: