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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50264018
Substrate
n/a
Meas. Tech.
ChEMBL_535520 (CHEMBL986146)
EC50
331±n/a nM
Citation
 Kim, E; Park, CS; Han, T; Bae, MH; Chong, W; Lee, CH; Shin, YA; Ahn, BN; Kim, MK; Shin, CY; Son, MH; Kim, JK; Moon, HS; Shim, HJ; Kim, EJ; Kim, SH; Lim, JI; Lee, CH Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARalpha/gamma dual agonists. Bioorg Med Chem Lett 18:4993-6 (2008) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50264018
Synonyms:
2-(3-(2-(4-(4-chlorophenyl)-5,6-dihydropyridin-1(2H)-yl)ethoxy)phenoxy)-2-methylpropanoic acid | CHEMBL489769
Type:
Small organic molecule
Emp. Form.:
C23H26ClNO4
Mol. Mass.:
415.91
SMILES:
CC(C)(Oc1cccc(OCCN2CCC(=CC2)c2ccc(Cl)cc2)c1)C(O)=O |c:15|
Structure:
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