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Target
Protein kinase domain-containing protein
Ligand
BDBM50264946
Substrate
n/a
Meas. Tech.
ChEMBL_496798 (CHEMBL1008811)
IC50
34000±n/a nM
Citation
 Bouloc, N; Large, JM; Smiljanic, E; Whalley, D; Ansell, KH; Edlin, CD; Bryans, JS Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7. Bioorg Med Chem Lett 18:5294-8 (2008) [PubMed]  Article 
Target
Name:
Protein kinase domain-containing protein
Synonyms:
Putative uncharacterized protein pk7
Type:
PROTEIN
Mol. Mass.:
37967.83
Organism:
Plasmodium falciparum
Description:
ChEMBL_496798
Residue:
320
Sequence:
MKDILSNYSNLIYLNKYVKEKDKYINDYRIIRTLNQGKFNKIILCEKDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSEDALVTAK
  
Inhibitor
Name:
BDBM50264946
Synonyms:
(S)-2-(3-(4-aminophenyl)imidazo[1,2-b]pyridazin-6-ylamino)-3-methylbutan-1-ol | CHEMBL498181 | US10688093, Compound 229_0254_0333 | US11701353, Compound 229_0254_0333
Type:
Small organic molecule
Emp. Form.:
C17H21N5O
Mol. Mass.:
311.3815
SMILES:
CC(C)[C@@H](CO)Nc1ccc2ncc(-c3ccc(N)cc3)n2n1 |r|
Structure:
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