Reaction Details Report a problem with these data
Target
Protein kinase domain-containing protein
Ligand
BDBM50264982
Substrate
n/a
Meas. Tech.
ChEMBL_496798 (CHEMBL1008811)
IC50
111000±n/a nM
Citation
 Bouloc, N; Large, JM; Smiljanic, E; Whalley, D; Ansell, KH; Edlin, CD; Bryans, JS Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7. Bioorg Med Chem Lett 18:5294-8 (2008) [PubMed]  Article 
Target
Name:
Protein kinase domain-containing protein
Synonyms:
Putative uncharacterized protein pk7
Type:
PROTEIN
Mol. Mass.:
37967.83
Organism:
Plasmodium falciparum
Description:
ChEMBL_496798
Residue:
320
Sequence:
MKDILSNYSNLIYLNKYVKEKDKYINDYRIIRTLNQGKFNKIILCEKDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSEDALVTAK
  
Inhibitor
Name:
BDBM50264982
Synonyms:
(S)-2-(4-(6-(1-hydroxy-3-methylbutan-2-ylamino)imidazo[1,2-b]pyridazin-3-yl)phenyl)acetic acid | CHEMBL497365
Type:
Small organic molecule
Emp. Form.:
C19H22N4O3
Mol. Mass.:
354.403
SMILES:
CC(C)[C@@H](CO)Nc1ccc2ncc(-c3ccc(CC(O)=O)cc3)n2n1 |r|
Structure:
Search PDB for entries with ligand similarity: