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Target
Heme oxygenase 1
Ligand
BDBM50252802
Substrate
n/a
Meas. Tech.
ChEMBL_539041 (CHEMBL1035715)
IC50
390±n/a nM
Citation
 Rahman, MN; Vlahakis, JZ; Szarek, WA; Nakatsu, K; Jia, Z X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors. J Med Chem 51:5943-52 (2008) [PubMed]  Article 
Target
Name:
Heme oxygenase 1
Synonyms:
HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1
Type:
Enzyme
Mol. Mass.:
33005.15
Organism:
Rattus norvegicus (rat)
Description:
HO-1 obtained from rat spleen was used in enzyme assays.
Residue:
289
Sequence:
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
  
Inhibitor
Name:
BDBM50252802
Synonyms:
4-(4-Bromophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanone Hydrochloride | CHEMBL493658
Type:
Small organic molecule
Emp. Form.:
C12H12BrN3O
Mol. Mass.:
294.147
SMILES:
Brc1ccc(CCC(=O)Cn2cncn2)cc1
Structure:
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