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Target
Hormone-sensitive lipase
Ligand
BDBM50147280
Substrate
n/a
Meas. Tech.
ChEMBL_538751 (CHEMBL1024870)
IC50
6±n/a nM
Citation
 Taha, MO; Dahabiyeh, LA; Bustanji, Y; Zalloum, H; Saleh, S Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of new potent hormone sensitive lipase inhibitors. J Med Chem 51:6478-94 (2008) [PubMed]  Article 
Target
Name:
Hormone-sensitive lipase
Synonyms:
Hormone-sensitive lipase | Hormone-sensitive lipase (HSL) | LIPS_RAT | Lipe
Type:
Enzyme
Mol. Mass.:
116814.94
Organism:
Rattus norvegicus (Rat)
Description:
P15304
Residue:
1068
Sequence:
MKPRRPISFTREITAMEPSSTSVSRPEWRPEAQQTLTDYPGSRELQEFGIPQKQSLPNEATAQQGAEFQQEQGVQQSTLLQKLLTPLAFPVPQQSFPSHKVHSDQQEATSQNGPGAGKVHTTQKELEHRDEHVGTAESGPAEPPPATEVEATSIAQAVSGPDKKLPTQTDLVSQERAEQSDPTAQQTPLVQGVKSDQGSLIESGILARLQKLAIQQPSQEWKTFLDCVTESDMEKYLNSSSKSNPPEPSGGTVIPGTLPSKQKPDCGKMSGYGGKLPHGKKGILQKHKHYWDTASAFSHSMDLRTMTQSLVALAEDNMAFFSSQGPGETARRLSNVFAGVREQALGLEPTLGQLLGVAHHFDLDTETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRASHNLAELEAYLAALTQLRALAYYAQRLLTINRPGVLFFEGDEGLSADFLQDYVTLHKGCFYGRCLGFQFTPAIRPFLQTLSIGLVSFGEHYKRNETGLSVTASSLFTGGRFAIDPELRGAEFERIIQNLDVHFWKAFWNITEIEVLSSLANMASTTVRVSRLLSLPPEAFEMPLTSDPKLTVTISPPLAHTGPGPVLARLISYDLREGQDSKMLNSLAKSEGPRLELRPRPQQAPRSRALVVHIHGGGFVAQTSKSHEPYLKNWAQELGVPIISIDYSLAPEAPFPRALEECFFAYCWAVKHCELLGSTGERICLAGDSAGGNLCITVSLRAAAYGVRVPDGIMAAYPVTTLQSSASPSRLLSLMDPLLPLSVLSKCVSAYSGTETEDHFDSDQKALGVMGLVQRDTSLFLRDLRLGASSWLNSFLELSGRKPHKTPLPATETLRPTDSGRLTESMRRSVSEAALAQPEGLLGTDSLKKLTIKDLSFKGNSEPSDSPEMSQSMETLGPSTPSDVNFFLRSGNSQEEAETRDDISPMDGIPRVRAAFPDGFHPRRSSQGVLHMPLYSSPIVKNPFMSPLLAPDVMLKTLPPVHLVACALDPMLDDSVMFARRLKDLGQPVTLKVVEDLPHGFLSLAALCRETRQAAELCVQRIRLILTPPAAPLT
  
Inhibitor
Name:
BDBM50147280
Synonyms:
3-Methyl-2-(4-methyl-piperidine-1-carbonyl)-4-(tetrahydro-thiopyran-4-yl)-2H-isoxazol-5-one | 3-methyl-2-(4-methylpiperidine-1-carbonyl)-4-(tetrahydro-2H-thiopyran-4-yl)isoxazol-5(2H)-one | CHEMBL108325
Type:
Small organic molecule
Emp. Form.:
C16H24N2O3S
Mol. Mass.:
324.438
SMILES:
CC1CCN(CC1)C(=O)n1oc(=O)c(C2CCSCC2)c1C
Structure:
Search PDB for entries with ligand similarity: