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Target
Cyclin-dependent kinase 2
Ligand
BDBM7672
Substrate
n/a
Meas. Tech.
ChEMBL_536407 (CHEMBL992478)
IC50
<3±n/a nM
Citation
 Anderson, M; Andrews, DM; Barker, AJ; Brassington, CA; Breed, J; Byth, KF; Culshaw, JD; Finlay, MR; Fisher, E; McMiken, HH; Green, CP; Heaton, DW; Nash, IA; Newcombe, NJ; Oakes, SE; Pauptit, RA; Roberts, A; Stanway, JJ; Thomas, AP; Tucker, JA; Walker, M; Weir, HM Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett 18:5487-92 (2008) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM7672
Synonyms:
4-[(4-{imidazo[1,2-a]pyridazin-3-yl}pyrimidin-2-yl)amino]-N-methylbenzene-1-sulfonamide | CHEMBL520003 | Imidazo[1,2-b]pyridazine deriv. 2b
Type:
Small organic molecule
Emp. Form.:
C17H15N7O2S
Mol. Mass.:
381.412
SMILES:
CNS(=O)(=O)c1ccc(Nc2nccc(n2)-c2cnc3cccnn23)cc1
Structure:
Search PDB for entries with ligand similarity: