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Target
Small conductance calcium-activated potassium channel protein 1
Ligand
BDBM50275960
Substrate
n/a
Meas. Tech.
ChEMBL_497520 (CHEMBL995895)
IC50
300±n/a nM
Citation
 Gentles, RG; Hu, S; Huang, Y; Grant-Young, K; Poss, MA; Andres, C; Fiedler, T; Knox, R; Lodge, N; Weaver, CD; Harden, DG Preliminary SAR studies on non-apamin-displacing 4-(aminomethylaryl)pyrrazolopyrimidine K(Ca) channel blockers. Bioorg Med Chem Lett 18:5694-7 (2008) [PubMed]  Article 
Target
Name:
Small conductance calcium-activated potassium channel protein 1
Synonyms:
KCNN1 | KCNN1_HUMAN | SK | Small conductance calcium-activated potassium channel protein 1 | Small conductance calcium-activated potassium channel protein 1 (KCa2.1)
Type:
Protein
Mol. Mass.:
60005.90
Organism:
Homo sapiens (Human)
Description:
Q92952
Residue:
543
Sequence:
MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPRGQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYLLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARVRKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDCG
  
Inhibitor
Name:
BDBM50275960
Synonyms:
5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine | CHEMBL472452
Type:
Small organic molecule
Emp. Form.:
C11H9ClN4S
Mol. Mass.:
264.734
SMILES:
Clc1cc(NCc2cccs2)n2nccc2n1
Structure:
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