Reaction Details Report a problem with these data
Target
Small conductance calcium-activated potassium channel protein 3
Ligand
BDBM50275793
Substrate
n/a
Meas. Tech.
ChEMBL_497517 (CHEMBL995892)
IC50
19100±n/a nM
Citation
 Gentles, RG; Hu, S; Huang, Y; Grant-Young, K; Poss, MA; Andres, C; Fiedler, T; Knox, R; Lodge, N; Weaver, CD; Harden, DG Preliminary SAR studies on non-apamin-displacing 4-(aminomethylaryl)pyrrazolopyrimidine K(Ca) channel blockers. Bioorg Med Chem Lett 18:5694-7 (2008) [PubMed]  Article 
Target
Name:
Small conductance calcium-activated potassium channel protein 3
Synonyms:
K3 | KCNN3 | KCNN3_HUMAN | Small conductance calcium-activated potassium channel protein 3 | Small conductance calcium-activated potassium channel protein 3 (KCa2.3)
Type:
Protein
Mol. Mass.:
82053.75
Organism:
Homo sapiens (Human)
Description:
Q9UGI6
Residue:
731
Sequence:
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC
  
Inhibitor
Name:
BDBM50275793
Synonyms:
5-chloro-N-(2-chlorobenzyl)pyrazolo[1,5-a]pyrimidin-7-amine | CHEMBL513561
Type:
Small organic molecule
Emp. Form.:
C13H10Cl2N4
Mol. Mass.:
293.151
SMILES:
Clc1cc(NCc2ccccc2Cl)n2nccc2n1
Structure:
Search PDB for entries with ligand similarity: