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Target
P2Y purinoceptor 1
Ligand
BDBM50245935
Substrate
n/a
Meas. Tech.
ChEMBL_558003 (CHEMBL965598)
IC50
1600±n/a nM
Citation
 Morales-Ramos, AI; Mecom, JS; Kiesow, TJ; Graybill, TL; Brown, GD; Aiyar, NV; Davenport, EA; Kallal, LA; Knapp-Reed, BA; Li, P; Londregan, AT; Morrow, DM; Senadhi, S; Thalji, RK; Zhao, S; Burns-Kurtis, CL; Marino, JP Tetrahydro-4-quinolinamines identified as novel P2Y(1) receptor antagonists. Bioorg Med Chem Lett 18:6222-6 (2008) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 1
Synonyms:
ATP receptor | P2RY1 | P2RY1_HUMAN | P2Y purinoceptor 1 (P2Y1) | P2Y1 | Purinergic receptor | Purinergic receptor P2Y1
Type:
Enzyme
Mol. Mass.:
42090.25
Organism:
Homo sapiens (Human)
Description:
P47900
Residue:
373
Sequence:
MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL
  
Inhibitor
Name:
BDBM50245935
Synonyms:
(2R,3S,4S)-2-ethyl-N-(3-methoxyphenyl)-3-methyl-4-(phenylamino)-3,4-dihydroquinoline-1(2H)-carboxamide | CHEMBL518823
Type:
Small organic molecule
Emp. Form.:
C26H29N3O2
Mol. Mass.:
415.5274
SMILES:
CC[C@@H]1[C@@H](C)[C@H](Nc2ccccc2)c2ccccc2N1C(=O)Nc1cccc(OC)c1 |r|
Structure:
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