Reaction Details Report a problem with these data
Target
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Ligand
BDBM50245798
Substrate
n/a
Meas. Tech.
ChEMBL_558191 (CHEMBL962325)
IC50
4323±n/a nM
Citation
 Bunnage, ME; Mathias, JP; Wood, A; Miller, D; Street, SD Highly potent and selective chiral inhibitors of PDE5: an illustration of Pfeiffer's rule. Bioorg Med Chem Lett 18:6033-6 (2008) [PubMed]  Article 
Target
Name:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Synonyms:
PDE6A | PDE6A_CANLF | PDEA
Type:
PROTEIN
Mol. Mass.:
99670.72
Organism:
Canis familiaris
Description:
ChEMBL_558191
Residue:
861
Sequence:
MGEVTAEQVEKFLDSNIIFAKQYYNLRYRAKVISDMLGAKEAAVDFSNYHSLSSVEESEIIFDLLRDFQENLQAERCIFNVMKKLCFLLQADRMSLFMYRVRNGIAELATRLFNVHKDAVLEECLVAPDSEIVFPLDMGVVGHVAHSKKIANVVNTEEDEHFCDFVDTLTEYQTKNILASPIMNGKDVVAVIMAVNKVDEPHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEAPPYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPTYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLAQFLGWSVLNPDTYESMNRLENRKDIFQDMVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEILQGELPDAEKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRRITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYETQQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDTKMKALEEEKQKQQTAKQGAAGDQPGGNPSPAGGAPASKSCCIQ
  
Inhibitor
Name:
BDBM50245798
Synonyms:
(R)-3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2-(1-(pyridin-2-yl)ethoxy)pyridin-3-yl)-2-methyl-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | CHEMBL455187
Type:
Small organic molecule
Emp. Form.:
C26H32N8O4S
Mol. Mass.:
552.648
SMILES:
CCN1CCN(CC1)S(=O)(=O)c1cnc(O[C@H](C)c2ccccn2)c(c1)-c1nc2c(CC)n(C)nc2c(=O)[nH]1 |r|
Structure:
Search PDB for entries with ligand similarity: