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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM50273757
Substrate
n/a
Meas. Tech.
ChEMBL_536039 (CHEMBL991609)
EC50
0.007586±n/a nM
Citation
 Murage, EN; Schroeder, JC; Beinborn, M; Ahn, JM Search for alpha-helical propensity in the receptor-bound conformation of glucagon-like peptide-1. Bioorg Med Chem 16:10106-12 (2008) [PubMed]  Article 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Homo sapiens (Human)
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
  
Inhibitor
Name:
BDBM50273757
Synonyms:
CHEMBL507037
Type:
Small organic molecule
Emp. Form.:
C149H223N41O46
Mol. Mass.:
3324.612
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O |r,wU:123.124,109.115,101.102,131.134,86.86,134.137,72.76,140.142,152.154,49.54,36.41,26.26,8.13,2.2,167.170,183.187,205.211,wD:118.119,90.98,80.82,68.68,146.148,58.57,31.31,17.22,4.4,178.183,197.203,212.218,225.231,(74.51,-9.27,;74.51,-7.72,;75.85,-6.96,;77.19,-7.73,;75.85,-5.42,;74.52,-4.65,;73.18,-5.42,;73.18,-6.95,;71.86,-4.65,;71.86,-3.11,;73.19,-2.34,;73.19,-.8,;71.85,-.03,;74.53,-.03,;70.52,-5.42,;69.18,-4.65,;69.19,-3.1,;67.85,-5.42,;67.84,-6.96,;69.18,-7.73,;69.18,-9.27,;70.51,-10.04,;70.51,-11.58,;66.52,-4.65,;65.18,-5.42,;65.18,-6.96,;63.86,-4.64,;63.86,-3.1,;62.51,-5.42,;61.18,-4.65,;61.19,-3.11,;59.85,-5.41,;59.84,-6.95,;58.52,-4.65,;57.18,-5.41,;57.17,-6.95,;55.85,-4.65,;55.85,-3.1,;57.18,-2.34,;57.18,-.79,;55.85,-.02,;58.52,-.03,;54.51,-5.42,;53.18,-4.65,;53.19,-3.1,;51.84,-5.42,;50.51,-4.64,;49.18,-5.42,;49.17,-6.95,;47.84,-4.64,;47.84,-3.1,;49.18,-2.33,;49.18,-.79,;47.85,-.02,;50.52,-.02,;46.51,-5.41,;45.18,-4.64,;45.18,-3.09,;43.84,-5.41,;43.84,-6.95,;45.17,-7.72,;45.17,-9.26,;46.51,-10.03,;43.84,-10.02,;30.51,-10.03,;29.17,-9.26,;29.17,-7.72,;27.84,-6.95,;27.84,-5.42,;26.51,-4.65,;25.17,-5.43,;25.17,-6.95,;23.84,-4.65,;23.84,-3.11,;25.18,-2.34,;26.5,-3.11,;25.18,-.8,;22.5,-5.42,;21.18,-4.66,;21.18,-3.11,;19.84,-5.41,;19.84,-6.95,;21.17,-7.72,;18.5,-4.65,;17.17,-5.42,;17.17,-6.95,;15.84,-4.66,;14.5,-5.42,;13.17,-4.65,;13.17,-3.12,;11.83,-5.43,;11.83,-6.95,;13.17,-7.73,;14.5,-6.96,;15.84,-7.72,;15.84,-9.26,;14.5,-10.03,;13.17,-9.26,;10.51,-4.66,;9.17,-5.42,;9.17,-6.95,;7.83,-4.65,;6.5,-5.43,;5.17,-4.65,;5.17,-3.11,;3.83,-5.42,;2.51,-4.65,;1.16,-5.43,;1.16,-6.96,;-.17,-4.65,;-.16,-3.12,;1.16,-2.34,;1.17,-.8,;-.17,-.02,;2.5,-.03,;-1.5,-5.42,;-2.83,-4.66,;-2.83,-3.11,;-4.17,-5.42,;-4.17,-6.95,;-5.49,-4.65,;-6.82,-5.42,;-6.82,-6.96,;-8.17,-4.65,;-9.5,-5.41,;-8.17,-3.11,;-6.82,-2.35,;-5.43,-2.96,;-4.4,-1.82,;-5.17,-.49,;-6.66,-.82,;7.84,-3.1,;6.5,-2.34,;9.17,-2.34,;15.84,-3.11,;14.51,-2.33,;17.17,-2.34,;29.18,-4.65,;29.18,-3.11,;30.51,-5.43,;31.85,-4.65,;31.85,-3.1,;33.18,-2.34,;33.17,-5.42,;33.17,-6.95,;34.51,-4.64,;35.85,-5.43,;35.84,-6.95,;37.18,-7.73,;37.18,-4.65,;37.18,-3.1,;38.51,-5.42,;39.85,-4.64,;39.85,-3.1,;41.19,-2.34,;42.51,-3.09,;43.84,-2.33,;43.84,-.79,;45.18,-.02,;42.52,-.03,;41.18,-.79,;41.18,-5.41,;41.17,-6.95,;42.51,-4.64,;77.19,-4.66,;77.19,-3.11,;78.52,-5.42,;79.85,-4.66,;79.86,-3.11,;81.19,-2.34,;82.52,-3.11,;83.86,-2.35,;83.86,-.81,;82.52,-.03,;81.19,-.81,;81.19,-5.42,;81.19,-6.96,;82.53,-4.65,;83.85,-5.42,;83.85,-6.96,;85.19,-4.65,;85.19,-3.11,;86.52,-5.43,;87.86,-4.65,;87.86,-3.11,;89.19,-2.35,;90.6,-2.97,;91.63,-1.83,;90.86,-.5,;91.34,.97,;90.31,2.11,;88.8,1.79,;88.33,.33,;89.35,-.82,;89.19,-5.43,;89.19,-6.97,;90.53,-4.66,;91.86,-5.43,;91.86,-6.96,;93.19,-7.74,;93.19,-9.27,;94.53,-6.97,;93.2,-4.66,;93.2,-3.12,;94.52,-5.43,;95.86,-4.66,;95.86,-3.12,;97.2,-2.36,;94.53,-2.35,;97.19,-5.43,;97.19,-6.97,;98.53,-4.67,;99.86,-5.43,;99.86,-6.97,;101.19,-7.74,;101.19,-9.28,;102.52,-10.05,;102.52,-11.59,;101.2,-4.66,;101.2,-3.12,;102.53,-5.43,;103.86,-4.66,;105.19,-5.44,;105.19,-6.97,;106.53,-4.66,;107.86,-5.44,;107.86,-6.98,;109.2,-7.75,;109.2,-9.29,;110.53,-10.06,;110.53,-11.6,;109.19,-12.36,;111.86,-12.37,;109.2,-4.66,;110.53,-5.44,;109.21,-3.12,)|
Structure:
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