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Target
Gag polyprotein
Ligand
BDBM50273883
Substrate
n/a
Meas. Tech.
ChEMBL_536774 (CHEMBL984568)
IC50
1400±n/a nM
Citation
 LaFrate, AL; Gunther, JR; Carlson, KE; Katzenellenbogen, JA Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor. Bioorg Med Chem 16:10075-84 (2008) [PubMed]  Article 
Target
Name:
Gag polyprotein
Synonyms:
GAG_AVIER | gag
Type:
PROTEIN
Mol. Mass.:
61664.68
Organism:
Avian erythroblastosis virus (strain ES4)
Description:
ChEMBL_536774
Residue:
555
Sequence:
REEQVTSEQAKFWLGLGGGRVSPPGPECIEKPATERRIDKGEEMGETTVQRDAKMAPEKMATPKTVGTSCYQCGTATGCNCVTASAPPPPYVGSGLYPSLAGAGEQGQGGDTPRGAEQPRAEPGHAGQAPGPALTDWARIREELASTGPPVVAMPVVIKTEGPAWTPLEPEDTRWLDGKHKRKSSQCLVKSSMSGYIPSCLDKDEQCVVCGDKATGYHYRCITCEGCKSFFRRTIQKNLHPTYSCTYDGCCVIDKITRNQCQLCRFKKCISVGMAMDLVLDDSKRVAKRKLIEENRERRRKEEMIKSLQHRPSPSAEEWELIHVVTEAHRSTNAQGSHWKQRRKFLLEDIGQSPMASMLDGDKVDLEAFSEFTKIITPAITRVVDFAKNLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLSGEMAVKREQLKNGGLGVVSDAIFDLGKSLSAFNLDDTEVALLQAVLLMSSDRTGLICVDKIEKCQESYLLAFEHYINYRKHNIPHFWSKLLMKVADLRMIGAYHASRFLHMKVECPTELSPQEV
  
Inhibitor
Name:
BDBM50273883
Synonyms:
CHEMBL460174 | beta-Chloro-alpha-methylcinnamaldehyde guanylhydrazone
Type:
Small organic molecule
Emp. Form.:
C11H13ClN4
Mol. Mass.:
236.701
SMILES:
[#6]-[#6](-[#6]=[#7]\[#7]=[#6](\[#7])-[#7])=[#6](Cl)-c1ccccc1 |w:2.1,1.0|
Structure:
Search PDB for entries with ligand similarity: