Reaction Details Report a problem with these data
Target
Gag polyprotein
Ligand
BDBM50273854
Substrate
n/a
Meas. Tech.
ChEMBL_536774 (CHEMBL984568)
IC50
3100±n/a nM
Citation
 LaFrate, AL; Gunther, JR; Carlson, KE; Katzenellenbogen, JA Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor. Bioorg Med Chem 16:10075-84 (2008) [PubMed]  Article 
Target
Name:
Gag polyprotein
Synonyms:
GAG_AVIER | gag
Type:
PROTEIN
Mol. Mass.:
61664.68
Organism:
Avian erythroblastosis virus (strain ES4)
Description:
ChEMBL_536774
Residue:
555
Sequence:
REEQVTSEQAKFWLGLGGGRVSPPGPECIEKPATERRIDKGEEMGETTVQRDAKMAPEKMATPKTVGTSCYQCGTATGCNCVTASAPPPPYVGSGLYPSLAGAGEQGQGGDTPRGAEQPRAEPGHAGQAPGPALTDWARIREELASTGPPVVAMPVVIKTEGPAWTPLEPEDTRWLDGKHKRKSSQCLVKSSMSGYIPSCLDKDEQCVVCGDKATGYHYRCITCEGCKSFFRRTIQKNLHPTYSCTYDGCCVIDKITRNQCQLCRFKKCISVGMAMDLVLDDSKRVAKRKLIEENRERRRKEEMIKSLQHRPSPSAEEWELIHVVTEAHRSTNAQGSHWKQRRKFLLEDIGQSPMASMLDGDKVDLEAFSEFTKIITPAITRVVDFAKNLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLSGEMAVKREQLKNGGLGVVSDAIFDLGKSLSAFNLDDTEVALLQAVLLMSSDRTGLICVDKIEKCQESYLLAFEHYINYRKHNIPHFWSKLLMKVADLRMIGAYHASRFLHMKVECPTELSPQEV
  
Inhibitor
Name:
BDBM50273854
Synonyms:
1-Methoxy-3,4-dihydronaphthalene-2-carboxaldehyde guanylhydrazone | CHEMBL456600
Type:
Small organic molecule
Emp. Form.:
C13H16N4O
Mol. Mass.:
244.2923
SMILES:
[#6]-[#8]-[#6]-1=[#6](-[#6]-[#6]-c2ccccc-12)-[#6]=[#7]\[#7]=[#6](\[#7])-[#7] |w:12.13,t:2|
Structure:
Search PDB for entries with ligand similarity: