Reaction Details Report a problem with these data
Target
Peptide deformylase
Ligand
BDBM50255033
Substrate
n/a
Meas. Tech.
ChEMBL_559976 (CHEMBL1014575)
IC50
21±n/a nM
Citation
 Pichota, A; Duraiswamy, J; Yin, Z; Keller, TH; Alam, J; Liung, S; Lee, G; Ding, M; Wang, G; Chan, WL; Schreiber, M; Ma, I; Beer, D; Ngew, X; Mukherjee, K; Nanjundappa, M; Teo, JW; Thayalan, P; Yap, A; Dick, T; Meng, W; Xu, M; Koehn, J; Pan, SH; Clark, K; Xie, X; Shoen, C; Cynamon, M Peptide deformylase inhibitors of Mycobacterium tuberculosis: synthesis, structural investigations, and biological results. Bioorg Med Chem Lett 18:6568-72 (2008) [PubMed]  Article 
Target
Name:
Peptide deformylase
Synonyms:
DEF_MYCTU | def
Type:
PROTEIN
Mol. Mass.:
20931.95
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_559976
Residue:
197
Sequence:
MAVVPIRIVGDPVLHTATTPVTVAADGSLPADLAQLIATMYDTMDAANGVGLAANQIGCSLRLFVYDCAADRAMTARRRGVVINPVLETSEIPETMPDPDTDDEGCLSVPGESFPTGRAKWARVTGLDADGSPVSIEGTGLFARMLQHETGHLDGFLYLDRLIGRYARNAKRAVKSHGWGVPGLSWLPGEDPDPFGH
  
Inhibitor
Name:
BDBM50255033
Synonyms:
CHEMBL463859 | N-((R)-3-((S)-2-(benzo[d]oxazol-2-yl)pyrrolidin-1-yl)-2-(cyclopropylmethyl)-3-oxopropyl)-N-hydroxyformamide
Type:
Small organic molecule
Emp. Form.:
C19H23N3O4
Mol. Mass.:
357.4036
SMILES:
ON(C[C@@H](CC1CC1)C(=O)N1CCC[C@H]1c1nc2ccccc2o1)C=O |r|
Structure:
Search PDB for entries with ligand similarity: