Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50255057
Substrate
n/a
Meas. Tech.
ChEMBL_558495 (CHEMBL963901)
IC50
4.79±n/a nM
Citation
 Kim, JY; Seo, HJ; Lee, SH; Jung, ME; Ahn, K; Kim, J; Lee, J Diarylimidazolyl oxadiazole and thiadiazole derivatives as cannabinoid CB1 receptor antagonists. Bioorg Med Chem Lett 19:142-5 (2008) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_RAT | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cnr1 | Skr6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52856.55
Organism:
Rattus norvegicus (rat)
Description:
P20272
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50255057
Synonyms:
2-(1-(4-bromophenyl)-2-(2,4-dichlorophenyl)-5-ethyl-1H-imidazol-4-yl)-5-(1-(4-chlorophenyl)cyclobutyl)-1,3,4-thiadiazole | CHEMBL520121
Type:
Small organic molecule
Emp. Form.:
C29H22BrCl3N4S
Mol. Mass.:
644.84
SMILES:
CCc1c(nc(-c2ccc(Cl)cc2Cl)n1-c1ccc(Br)cc1)-c1nnc(s1)C1(CCC1)c1ccc(Cl)cc1
Structure:
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