Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetDual specificity phosphatase Cdc25B
LigandBDBM24777
Substrate/Competitorn/a
Meas. Tech.ChEMBL_565115
IC50 1980±n/a nM
Citation Cao, SMurphy, BTFoster, CLazo, JSKingston, DG Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem17:2276-81 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity phosphatase Cdc25B
Name:Dual specificity phosphatase Cdc25B
Synonyms:Dual specificity phosphatase (CDC25B) | M-phase inducer phosphatase 2 (CDC25B)
Type:Protein
Mol. Mass.:64985.27
Organism:Homo sapiens (Human)
Description:n/a
Residue:580
Sequence:
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMH
DLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMD
PHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEA
GSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPD
RKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKT
LEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQ
QEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETM
VALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKR
VILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQ
DYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM24777
NameBDBM24777
Synonyms:5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hydroxy-1,4-naphthoquinone, 4 | CHEMBL43612 | Juglone | Juglone (6a)
TypeSmall organic molecule
Emp. Form.C10H6O3
Mol. Mass.174.1528
SMILESOc1cccc2C(=O)C=CC(=O)c12 |c:8|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a