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TargetMKP-3
LigandBDBM24777
Substrate/Competitorn/a
Meas. Tech.ChEMBL_565117
IC50 12400±n/a nM
Citation Cao, SMurphy, BTFoster, CLazo, JSKingston, DG Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem17:2276-81 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
MKP-3
Name:MKP-3
Synonyms:MAP kinase phosphatase 3 | Mitogen-activated protein kinase phosphatase 3
Type:Enzyme
Mol. Mass.:42303.19
Organism:Rattus norvegicus
Description:gi_16758752
Residue:381
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNEQLLLMDCRPQELYESSHIESAINVAIPG
IMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLK
KLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDI
ESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVT
PNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRS
VTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQ
QLYFTAPSNQNVYQVDSLQST
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM24777
NameBDBM24777
Synonyms:5-hydroxy-1,4-dihydronaphthalene-1,4-dione | 5-hydroxy-1,4-naphthoquinone, 4 | CHEMBL43612 | Juglone | Juglone (6a)
TypeSmall organic molecule
Emp. Form.C10H6O3
Mol. Mass.174.1528
SMILESOc1cccc2C(=O)C=CC(=O)c12 |c:8|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a