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Target
Matrix metalloproteinase-16
Ligand
BDBM50066658
Substrate
n/a
Meas. Tech.
ChEMBL_561991 (CHEMBL1010054)
IC50
6.8±n/a nM
Citation
 Marques, SM; Nuti, E; Rossello, A; Supuran, CT; Tuccinardi, T; Martinelli, A; Santos, MA Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates. J Med Chem 51:7968-79 (2008) [PubMed]  Article 
Target
Name:
Matrix metalloproteinase-16
Synonyms:
C8orf57 | MMP-16 | MMP-X2 | MMP16 | MMP16_HUMAN | MMPX2 | MT-MMP 3 | MT3-MMP | MT3MMP | MTMMP3 | Matrix metalloproteinase 16 | Matrix metalloproteinase-16 | Membrane-type matrix metalloproteinase 3 | Membrane-type-3 matrix metalloproteinase
Type:
PROTEIN
Mol. Mass.:
69536.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_799129
Residue:
607
Sequence:
MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV
  
Inhibitor
Name:
BDBM50066658
Synonyms:
(R)-N-(1-(hydroxyamino)-2-methylpropyl)-4-methoxy-N-(pyridin-3-ylmethyl)benzenesulfonamide hydrochloride | (R)-N-Hydroxy-2-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-3-methyl-butyramide | (R)-N-Hydroxy-2-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-3-methyl-butyramide; hydrochloride | (R)-N-Hydroxy-2-isopropyl-3-(4-methoxy-benzenesulfonyl)-4-pyridin-3-yl-butyramide; hydrochloride | (R)-N-hydroxy-2-(4-methoxy-N-(pyridin-3-ylmethyl)phenylsulfonamido)-3-methylbutanamide | (S)-N-Hydroxy-2-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-3-methyl-butyramide | (S)-N-hydroxy-2-(4-methoxy-N-(pyridin-3-ylmethyl)phenylsulfonamido)-3-methylbutanamide | 2-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-N-hydroxy-3-methyl-butyramide(CGS-27023A) | 3-[((R)-1-Hydroxycarbamoyl-2-methyl-propylamino)-methyl]-pyridine-4-sulfonic acid methyl ester | CGS-27023 | CGS-27023A | CHEMBL514138 | N-Hydroxy-2-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-3-methyl-butyramide | N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)-amino]-3-methyl-butanamide
Type:
Small organic molecule
Emp. Form.:
C18H23N3O5S
Mol. Mass.:
393.457
SMILES:
COc1ccc(cc1)S(=O)(=O)N(Cc1cccnc1)[C@H](C(C)C)C(=O)NO
Structure:
Search PDB for entries with ligand similarity: