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TargetC-X-C chemokine receptor type 4 (CXCR4)
LigandBDBM50247015
Substrate/Competitorn/a
Meas. Tech.ChEMBL_556955
IC50 3.1±n/a nM
Citation Thoma, GStreiff, MBKovarik, JGlickman, FWagner, TBeerli, CZerwes, HG Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo. J Med Chem51:7915-20 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-X-C chemokine receptor type 4 (CXCR4)
Name:C-X-C chemokine receptor type 4
Synonyms:C-X-C chemokine receptor type 4 | CD_antigen=CD184 | CXC-R4 | CXCR-4 | FB22 | Fusin | HM89 | LCR1 | LESTR | Leukocyte-derived seven transmembrane domain receptor | NPYRL | SDF-1 receptor | Stromal cell-derived factor 1 receptor
Type:Enzyme
Mol. Mass.:39754.61
Organism:Homo sapiens (Human)
Description:P61073
Residue:352
Sequence:
MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVI
LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNL
YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA
DDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKT
TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPI
LYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
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  Blast E-value cutoff:
BDBM50247015
NameBDBM50247015
Synonyms:1,3-dicycloheptyl-2-((5,6-dihydroimidazo[2,1-b]thiazol-3-yl)methyl)isothiourea | CHEMBL508054
TypeSmall organic molecule
Emp. Form.C21H34N4S2
Mol. Mass.406.651
SMILESC(S\C(NC1CCCCCC1)=N/C1CCCCCC1)C1=CSC2=NCCN12 |t:21,24|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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