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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50246766
Substrate
n/a
Meas. Tech.
ChEMBL_561011 (CHEMBL1015251)
Ki
28±n/a nM
Citation
 Milczek, EM; Bonivento, D; Binda, C; Mattevi, A; McDonald, IA; Edmondson, DE Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B. J Med Chem 51:8019-26 (2008) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM50246766
Synonyms:
CHEMBL489079 | Mofegiline | US9302986, Mofegiline
Type:
Small organic molecule
Emp. Form.:
C11H13F2N
Mol. Mass.:
197.2244
SMILES:
NC\C(CCc1ccc(F)cc1)=C\F
Structure:
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