Reaction Details Report a problem with these data
Target
Arylamine N-acetyltransferase 1
Ligand
BDBM50275074
Substrate
n/a
Meas. Tech.
ChEMBL_494096 (CHEMBL942268)
IC50
138±n/a nM
Citation
 Russell, AJ; Westwood, IM; Crawford, MH; Robinson, J; Kawamura, A; Redfield, C; Laurieri, N; Lowe, ED; Davies, SG; Sim, E Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2. Bioorg Med Chem 17:905-18 (2009) [PubMed]  Article 
Target
Name:
Arylamine N-acetyltransferase 1
Synonyms:
AAC1 | ARY1_HUMAN | NAT1
Type:
PROTEIN
Mol. Mass.:
33898.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1347886
Residue:
290
Sequence:
MDIEAYLERIGYKKSRNKLDLETLTDILQHQIRAVPFENLNIHCGDAMDLGLEAIFDQVVRRNRGGWCLQVNHLLYWALTTIGFETTMLGGYVYSTPAKKYSTGMIHLLLQVTIDGRNYIVDAGFGRSYQMWQPLELISGKDQPQVPCVFRLTEENGFWYLDQIRREQYIPNEEFLHSDLLEDSKYRKIYSFTLKPRTIEDFESMNTYLQTSPSSVFTSKSFCSLQTPDGVHCLVGFTLTHRRFNYKDNTDLIEFKTLSEEEIEKVLKNIFNISLQRKLVPKHGDRFFTI
  
Inhibitor
Name:
BDBM50275074
Synonyms:
(Z)-5-(3',5'-Diiodo-4'-hydroxybenzylidene)-2-thioxothiazolidine-4-one | CHEMBL458614
Type:
Small organic molecule
Emp. Form.:
C10H5I2NO2S2
Mol. Mass.:
489.091
SMILES:
Oc1c(I)cc(C=C2SC(S)=NC2=O)cc1I |w:6.5,c:10|
Structure:
Search PDB for entries with ligand similarity: