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Target
Proto-oncogene Wnt-3
Ligand
BDBM50265504
Substrate
n/a
Meas. Tech.
ChEMBL_560815 (CHEMBL1012645)
EC50
710±n/a nM
Citation
 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J Med Chem 52:105-16 (2009) [PubMed]  Article 
Target
Name:
Proto-oncogene Wnt-3
Synonyms:
INT4 | Proto-oncogene protein Wnt-3 | WNT3 | WNT3_HUMAN
Type:
PROTEIN
Mol. Mass.:
39653.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_576549
Residue:
355
Sequence:
MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK
  
Inhibitor
Name:
BDBM50265504
Synonyms:
(R)-5-(phenylsulfonyl)-N-(1-(pyrrolidine-2-carbonyl)piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide | 5-(Phenylsulfonyl)-N-(1-D-prolylpiperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide | CHEMBL495536
Type:
Small organic molecule
Emp. Form.:
C23H26F3N3O5S2
Mol. Mass.:
545.595
SMILES:
FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@H]1CCCN1)S(=O)(=O)c1ccccc1 |r|
Structure:
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