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Target
Secreted frizzled-related protein 1
Ligand
BDBM50265499
Substrate
n/a
Meas. Tech.
ChEMBL_560813 (CHEMBL1011781)
IC50
30±n/a nM
Citation
 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J Med Chem 52:105-16 (2009) [PubMed]  Article 
Target
Name:
Secreted frizzled-related protein 1
Synonyms:
FRP | FRP1 | SARP2 | SFRP1 | SFRP1_HUMAN
Type:
PROTEIN
Mol. Mass.:
35404.91
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1363191
Residue:
314
Sequence:
MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK
  
Inhibitor
Name:
BDBM50265499
Synonyms:
CHEMBL495534 | N-[1-(1H-Imidazol-1-ylacetyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C23H23F3N4O5S2
Mol. Mass.:
556.578
SMILES:
FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)Cn1ccnc1)S(=O)(=O)c1ccccc1
Structure:
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