Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50256492
Substrate
n/a
Meas. Tech.
ChEMBL_515145 (CHEMBL1024667)
Ki
0.3±n/a nM
Citation
 Neustadt, BR; Liu, H; Hao, J; Greenlee, WJ; Stamford, AW; Foster, C; Arik, L; Lachowicz, J; Zhang, H; Bertorelli, R; Fredduzzi, S; Varty, G; Cohen-Williams, M; Ng, K Potent and selective adenosine A2A receptor antagonists: 1,2,4-Triazolo[1,5-c]pyrimidines. Bioorg Med Chem Lett 19:967-71 (2009) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50256492
Synonyms:
CHEMBL480570 | N7-(2-(4-(2,4-difluorophenyl)piperazin-1-yl)ethyl)-N7-methyl-2-(3-methylpyrazin-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Type:
Small organic molecule
Emp. Form.:
C23H26F2N10
Mol. Mass.:
480.5163
SMILES:
CN(CCN1CCN(CC1)c1ccc(F)cc1F)c1cc2nc(nn2c(N)n1)-c1nccnc1C
Structure:
Search PDB for entries with ligand similarity: